Valencia will meet Olympique Marseille in the UEFA Cup final after a 1-0 aggregate win over Villarreal.
The Spanish club have the possibility of a first domestic and European double when they face Villarreal in the UEFA Cup semi-final.
Images from the English Premier League matches played on Monday
Higuain had a disappointing Copa America tournament in July, scoring two goals during the competition and missing his spot kick as Argentina lost on penalties to Chile in the final.
News of all that's transpired on and off the football field
The Frenchman nodded home an Isco cross after 55 minutes against a well-organised Granada side that attacked with pace.
Portugal's Nani is poised to make his 99th appearance for his country in a crunch clash with Hungary on Wednesday and has been an automatic choice for the Selecao for a decade, yet there is a feeling the forward has not fulfilled his dazzling potential. Nani, blessed with searing pace, mesmerisingly quick feet and more tricks than a children's entertainer, will turn 30 in November and Euro 2016 could give the Fenerbahce star the platform for a transfer back to one of Europe's elite leagues. Scorer of Portugal's sole goal at the tournament - a neat finish in a 1-1 draw with Iceland - Nani has so far outperformed his captain and former Manchester United team mate Cristiano Ronaldo although he should have added to his tally of 18 international goals in Saturday's stalemate against Austria.
Sevilla missed a chance to get their La Liga campaign up and running when the Europa League holders surrendered the lead and were held to a 1-1 draw at Levante on Friday.
Ruben Baraja scored two goals as Valencia rallied to sink regional neighbours Villarreal 4-2 in the Spanish League.
Atletico Madrid's Jackson Martinez scored his first goal for the club when he came off the bench and curled in a superb effort to seal a hard-fought 3-0 victory at Sevilla in La Liga on Sunday.
Yes, it's that time of year again when people start hurling mushy tomatoes at each other in the street of Spain for absolutely no reason.
Manchester United stayed in fifth place, one point above West Ham, but it was another depressingly dull day at Old Trafford where United were booed off after losing 1-0 to Southampton.
The Primera Liga league leaders missed a chance to stretch their lead at the top when they were held to a 0-0 draw by Real Sociedad.
Holders FC Barcelona have been placed in Group E, along with Bayer Leverkusen, AS Roma, Dinamo Zagreb.
Atletico Madrid maintained a two-point lead in La Liga with a 3-0 victory at Las Palmas and Barcelona and Real Madrid stayed hard on their heels with thumping wins over Athletic Bilbao and Sporting Gijon on Sunday.
Champions Barcelona begin their bid for a sixth La Liga title in eight years at Athletic Bilbao on Sunday knowing that fellow heavyweights Real Madrid could, unusually, be just one of several challengers for their crown.
Second division Mirandes caused an upset by knocking Deportivo La Coruna out of the King's Cup on Tuesday and Sevilla joined them in the quarter-finals after making light work of city rivals Real Betis.
Aston Villa beat Crystal Palace 1-0 to win a Premier League match for the first time since August while a late goal from Paul Dummett earned a 3-3 draw for Newcastle United against Manchester United on Tuesday.
Athletic Bilbao's Spanish Super Cup victory against Barcelona not only earned them their first major trophy in 31 years but also ended coach Ernesto Valverde's long wait for silverware.
Lionel Messi struck a spectacular free kick, scored another goal and set up two more in a 4-1 victory for Barcelona over nine-man city rivals Espanyol in the first leg of their King's Cup last-16 clash on Wednesday.
Real Madrid have sacked coach Rafa Benitez after less than half a season in charge and promoted their former France great Zinedine Zidane from the B team to replace him, president Florentino Perez said on Monday.
Manchester City are brimming with optimism with coach Manuel Pellegrini 'absolutely sure' of winning the Premier League title.
Liverpool, level on points with Manchester United, can add to the pressure if they take three points at West Ham United in Saturday's lunchtime kickoff.
Sinisa Mihajlovic has set AC Milan a top-three finish as the target for his first season in charge of the seven-times European champions.
Britain number one Andy Murray has overtaken 14-time Grand Slam champion Rafael Nadal to claim the third spot in the ATP world rankings.
Juventus's new signing Sami Khedira will miss the first two months of the season with a thigh injury, the Serie A champions said.
Rajat Chauhan ensured India a medal by making the final in the compound section, while Laxmirani Majhi advanced to the bronze medal play-off in the women's recurve in the World Archery Championships, in Copenhagen, on Thursday.
Barcelona closed in on the La Liga title by thrashing local rivals Espanyol 5-0 on Sunday as Atletico Madrid dropped out of the race after losing 2-1 at Levante and Real Madrid beat Valencia 3-2.
Atletico Madrid ended a run of 23 league derbies without a win when Diego Costa struck early to clinch a 1-0 victory over city rivals Real Madrid at the Bernabeu on Saturday.
New Valencia coach Gary Neville remains without a La Liga win after his side twice recovered from a goal down to rescue a fortunate 2-2 draw at home to Getafe on Saturday.
Lionel Messi assumed the rare role of fan on Thursday conveying his best wishes to his idol and Argentina great Pablo Aimar who retired on Wednesday.
The top seed breezed to a 6-2, 6-4 victory over Christophe Rochus in the final.
Manchester United continued to splash the cash after Torino announced that Italy full back Matteo Darmian was heading to Old Trafford.
Juan Carlos Ferrero moved smartly into the quarter-finals with a 6-4, 6-4 victory over fellow Spaniard Albert Portas.
Argentine Franco Squillari provided the shock of the first round at the Valencia Open by beating the second seed 6-4, 5-7, 6-2